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About Cyclosporine

Gengraf Cyclosporine is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. Gengraf capsules are usually taken along with other medications to allow your new organ to function normally. Cyclosporine Gengraf medication belongs to a class of drugs known as immunosuppressants. Gengraf medication works by weakening the immune system to help your body accept the new organ as if it were your own. Gengraf side effects can be based on your medical condition.

How to use

  • Take Gengraf Cyclosporine by mouth as directed by your doctor.
  • Usually once daily.
  • You may take Gengraf capsules with or without food, but it is important to choose one way and take this medication the same way with every dose.
  • The dosage is based on your weight, medical condition, lab tests, and response to treatment.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with Gengraf medication. Ask your doctor or pharmacist for more details.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Side effects

  • Shaking
  • headache
  • dizziness
  • unusual growth of body hair
  • nausea/vomiting
  • diarrhea
  • stomach upset
  • flushing

If any of these Gengraf side effects last or get worse, tell your doctor or pharmacist promptly.

Unusual growth and swelling of the gums may occur. Brush your teeth and floss daily to reduce this problem. See your dentist regularly.

Remember that your doctor has prescribed Gengraf Cyclosporine because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious Gengraf side effects.

Gengraf medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Your doctor may control your blood pressure with medication.

Tell your doctor right away if you have any serious Gengraf side effects, including signs of kidney problems (such as a change in the amount of urine), signs of liver disease (such as nausea/vomiting that doesn’t stop, dark urine, yellowing eyes/skin, stomach/abdominal pain), easy bruising/bleeding, unusual tiredness, muscle weakness/spasms, slow/irregular heartbeat, numb/tingling skin, severe leg pain.

Get medical help right away if you have any very serious Gengraf side effects, including mental/mood changes (such as confusion, difficulty concentrating), vision changes, problems with speech, clumsiness, loss of coordination, weakness on one side of the body, chest pain, seizures.

A very serious allergic reaction to Gengraf medication is rare. However, get medical help right away.

Warnings & Precautions

  1. Before taking Gengraf Cyclosporine, tell your doctor or pharmacist if you are allergic to it.
  2. Before using Gengraf capsules, tell your doctor or pharmacist your medical history.
  3. Do not drive, use machinery, or do anything that needs alertness until you can do it safely.
  4. Limit alcoholic beverages.
  5. Before having surgery, tell your doctor or dentist about all the products you use.
  6. Avoid contact with people who have infections that may spread to others.
  7. Limit your time in the sun.
  8. Avoid tanning booths and sunlamps.
  9. Do not have immunizations/vaccinations.

Gengraf Cyclosporine may contain alcohol. Caution is advised if you are pregnant or breastfeeding or have liver disease, alcohol dependence, or any other condition that requires you to limit/avoid alcohol in your diet. Ask your doctor or pharmacist about using this product safely.

Gengraf capsules may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.

Older adults may be at greater risk for kidney problems or high blood pressure while using this drug.

During pregnancy, Gengraf medication should be used only when clearly needed. It may harm an unborn baby or cause other problems with the baby such as being born too early (premature) or having low birth weight. Discuss the risks and benefits with your doctor.

Gengraf capsules passes into breast milk. Because of the possible risk to the infant, breastfeeding while using this drug is not recommended. Consult your doctor before breastfeeding.


Store in the original blister pack at room temperature away from heat and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Drug interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.




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