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What is Linaclotide?

What is Linaclotide? Linaclotide Linzess is used for treating certain types of bowel problems (irritable bowel syndrome with constipation, chronic idiopathic constipation). Linzess medication works by increasing fluid in your intestines and helping speed up the movement of food through the gut. Linaclotide drug class may improve stool texture and lessen symptoms such as bloating, abdominal pain/discomfort, straining, and feelings of incomplete bowel movements.

Linaclotide Linzess is used for only children younger than 6 years because of the risk of serious side effects.

How to use

Read the Medication Guide provided by your pharmacist before you start taking Linzess medication and each time you get a refill. If you have any questions about What is Linaclotide or what Linaclotide Linzess is used for? ask your doctor or pharmacist.

  • Take the Linaclotide drug class by mouth on an empty stomach as directed by your doctor.
  • Usually once daily at least 30 minutes before your first meal of the day.
  • Swallow the capsules whole.
  • Do not break or chew the capsules.
  • If you have trouble swallowing the capsule, it may be opened and the contents mixed in a teaspoonful of applesauce.
  • Swallow the mixture right away, without chewing it.
  • Do not save the mixture for future use.

You may also empty the capsule’s content into an ounce (30 milliliters) of water. Swirl the mixture for 20 seconds and drink right away, without chewing it. Add another ounce (30 milliliters) of water to the cup, swirl for 20 seconds, and drink right away to get your whole dose. The water mixture may also be given through a tube into the stomach (nasogastric or gastric tube). If you are giving this medication through a tube, ask your health care professional for detailed instructions on how to give it.

Linaclotide drug class dosage is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Tell your doctor if your condition does not improve or if it worsens.

Side effects

  • Diarrhea
  • bloating
  • gas
  • stomach/abdominal pain/discomfort

If any of these Linzess medication effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed the Linaclotide drug class because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Stop taking this medication and tell your doctor right away if you have any serious side effects, including severe diarrhea.

A very serious allergic reaction to Linzess medication is rare. However, get medical help right away.

Warnings & Precautions

  1. Before taking Linzess medication, tell your doctor or pharmacist if you are allergic to it.
  2. Before using the Linaclotide drug class, tell your doctor or pharmacist your medical history.
  3. Tell your doctor or dentist about all the products you use, before having surgery.

During pregnancy, use this medication only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if Linzess medication passes into breast milk. Consult your doctor before breastfeeding.


Store in the original container at room temperature away from light and moisture. To help protect from moisture, keep the desiccant in the tightly closed container. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Consult your pharmacist or local waste disposal company.

Drug interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

A product that may interact with this drug is pramlintide.



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