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Estrogens, Conjugated



About Estrogens, Conjugated

Estrogen supplements are female hormones. Estrogens Conjugated is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen.Ā If you are using Estrogens hormones to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. Premarin vaginal cream is a mixture of estrogenĀ hormones. Estrogens effects can be based on your medical condition.

Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment.

Certain estrogen products may also be used by men and women to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).

How to use

Read the Patient Information Leaflet if available from your pharmacist before you start using Estrogen supplements and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

  • Take Estrogens Conjugated by mouth with or without food as directed by your doctor.
  • You may take it with food or right after a meal to prevent stomach upset.
  • If you are taking the extended-release tablets, do not crush, chew, or dissolve them.
  • Doing so can release all of the drugs at once, increasing the risk of side effects.
  • Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so.
  • Swallow the whole or split tablet without crushing or chewing.

Premarin vaginal cream dosage is based on your medical condition and response to treatment.

Take Estrogens hormones pills regularly to get the most benefit from them. To help you remember, take it at the same time(s) each day as directed. Follow your dosing schedule carefully. Do not increase your dose or take this medication more often or for a longer time than directed.

Tell your doctor if your condition does not improve or if it worsens.

Side effects

  • Stomach upset
  • nausea/vomiting
  • bloating
  • breast tenderness
  • headache
  • weight changes

Before any of these Estrogens effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor promptly if you see the tablet in your stool.

Remember that your doctor has prescribed Estrogens Conjugated because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious Estrogens effects.

Tell your doctor right away before you have any serious Estrogens effects, including

  • mental/mood changes
  • breast lumps
  • unusual vaginal bleeding
  • increased or new vaginal irritation/itching/odor/discharge
  • severe stomach/abdominal pain
  • persistent nausea/vomiting
  • yellowing eyes/skin, dark urine
  • swelling hands/ankles/feet
  • increased thirst/urination

Some serious and rare side effects

Estrogen supplements may rarely cause serious problems from blood clots (such as heart attacks, strokes, deep vein thrombosis, pulmonary embolism). Get medical help right away if you have any serious Estrogens effects, including chest/jaw/left arm pain, unusual sweating, sudden/severe headache, weakness on one side of the body, confusion, slurred speech, sudden vision changes (such as partial/complete blindness), pain/redness/swelling of legs, tingling/weakness/numbness in the arms/legs, trouble breathing, coughing up blood, sudden dizziness/fainting.

Moreover, a very serious allergic reaction to Estrogens hormonesĀ is rare. However, get medical help right away.

Ā Warnings & Precautions
  1. Before taking Estrogen supplements, tell your doctor or pharmacist if you are allergic to them.
  2. Before using Estrogens Conjugated, tell your doctor or pharmacist your medical history.
  3. Do not smoke or use tobacco.
  4. Limit your time in the sun.
  5. Avoid tanning booths and sunlamps.
  6. Tell your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time (such as a long plane flight).

If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Contact your eye doctor if these problems occur.

Children may be more sensitive to the side effects of Estrogens Conjugated. It may affect their growth/development. Moreover, discuss the possible effects of Estrogens hormones with the doctor, and monitor your child’s growth periodically.

Moreover, Estrogen supplements must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor right away.

Estrogens hormones pass into breast milk. Premarin vaginal cream may reduce the quality and amount of breast milk produced. Consult your doctor before breastfeeding.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Consult your pharmacist or local waste disposal company.

pharmacist or local waste disposal company.

Drug interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include aromatase inhibitors (such as anastrozole, exemestane, letrozole), fulvestrant, ospemifene, raloxifene, tamoxifen, toremifene, tranexamic acid.

This medication may interfere with certain laboratory tests (including metyrapone test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Premarin vaginal cream.



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